Intrepid researcher Dr Lily Houghton journeys to the Amazon and enlists the wisecracking skipper of a ramshackle boat, Frank Wolff, to be her guide as she seeks to uncover an ancient tree with unparalleled healing abilities. Thrust on this epic quest together, the unlikely duo encounters unnumerable dangers and supernatural forces as the secrets of the lost tree unfold leaving the fate of all mankind hanging in the balance.